Pathological hallmarks, clinical parallels, and value for drug testing in Alzheimer’s disease of the APP[V717I] London transgenic mouse model.
Abstract | The APP[V717I] London (APP-Ld) mouse model recapitulates important pathological and clinical hallmarks of Alzheimer’s disease (AD) and is therefore a valuable paradigm for evaluating therapeutic candidates. Historically, both the parenchymal and vascular amyloid deposits, and more recently, truncated and pyroglutamate-modified Abeta3(pE)–42 species, are perceived as important hallmarks of AD-pathology. Late stage symptoms are preceded by robust deficits in orientation and memory that correlate in time with Abeta oligomerization and GSK3β-mediated phosphorylation of endogenous murine Tau, all markers that have gained considerable interest during the last decade. Clinical parallels with AD patients and the value of the APP-Ld transgenic mouse model for preclinical in vivo testing of candidate drugs are discussed.
Download our paper to learn more about:
- The pathological hallmarks of our APP-Ld transgenic mouse model
- Clinical parallels between AD patients and our APP-Ld transgenic mouse model
- The value of the APP-Ld transgenic mouse model for preclinical in vivo testing of AD candidate drugs
- The added value of our bigenic models, combining APP-Ld with clinical mutants of hPS1 or hTAU
- New (early and late) neuropathological markers of the APP-Ld transgenic mouse model
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