Tau.P301S model data

reMYND’s Tau.P301S model is characterized by an age dependent hyperphosporylation and conformational change of Tau which correlates with the behavioural deficit rendering this model ideal for testing Tau-directed therapies.

Hyperphosphorylation in the model have been extensively characterized biochemically and immunohistochemistry using a multitude of phospho-epitope-specific antibodies such as AD2 (pS396/404), AT100 (pT212/S214), pS396, AT8 (pS202/pT205) and the AT180 (pT231) antibodies (figure 1, 2). The inter-mouse onset of the pathology shows little variability and strongly correlates with motor phenotype.

AT100

Figure 1: AT100 (phospho Tau pT212/S214) reactive cells in cortex, brainstem and hippocampus. Quantification data available on request.

AT100 in cortex

Figure 2: AT100 measured in cortex and brainstem using biochemistry (left) and rotarod performance (right). Additional quantification data (epitopes or age series) available on request.

A proprietary data package on the Tau.P301S model is available on request. Please contact Bart Roucourt, CRO Manager, for any inquiries.