Orphan programs

reMYND’s technology platform is amenable to address numerous other, highly debilitating protein-misfolding disorders, such as Huntington’s disease or Amyotrophic Lateral Sclerosis, to discover and develop first-in-class drug candidates. For instance, our Huntington program rescues huntingtin-driven neuronal  toxicity by inhibiting JNK activity and mitigating ER Ca2+ leakage through a novel proprietary target. This program improves neurite outgrowth and arborisation ex-vivo in R6/1 and wild-type neurons at the same level as BDNF, and reduces pJNK levels in wild type mice after acute administration.