APPxPS1 model

Key characteristics


Progressive total plaque load (an anti-Aβ antibody) and dense plaque load (Thioflavin S) in the subiculum as measured by IHC (mean ± SEM, N = 10).


Data from a study (Easton et al., 2013) that showed a significant  improvement in reference memory in APPxPS1 mice along with a dose-dependent reduction in brain Aβ. These results suggest that donepezil may alleviate cognitive impairments in Alzheimer’s disease, in part, by reducing brain Aβ.

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Describing papers:

Therapeutic intervention papers: