Tau[P301S] model

Key characteristics


Age dependent increase of Tau pathology (AT8 = pSer202 pThr205 Tau) in the frontal cortex, as measured by IHC (mean ± SEM, n = 10).


Progressive rotarod performance deficit, starting from 4 months of age. Time on the rod at a fixed speed of 10 rpm was measured (mean ± SEM, n = 15). Statistics: Two-way ANOVA, Sidak’s multiple comparison.


Long term potentiation deficit (induced by a high frequency stimulation) in the CA1 region of the hippocampus in 3.5 month old TAU[P301S] animals and age-matched controls (mean ± SEM, n = 5 per group). Statistics: Welches’ unpaired t test

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Describing papers:

Therapeutic intervention papers: